A metabolite; found in urine of patients with 3-methycrotonyl glycinuria; inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner; inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum

3-Methylcrotonyl Glycine – 10 mg

Brand:
Cayman
CAS:
33008-07-0
Storage:
-20
UN-No:
Non-Hazardous - /

3-Methylcrotonyl glycine (3-MCG) is a metabolite found in the urine of patients with 3-methylcrotonyl glycinuria, a metabolic disorder characterized by a deficiency in 3-methylcrotonyl-CoA carboxylase, that has diverse biological activities.{36412,36413} It inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner.{36413} It also inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum, indicating a potential role for this metabolite in the development of CNS damage associated with 3-methycrotonyl glycinuria.  

 

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Description

A metabolite; found in urine of patients with 3-methycrotonyl glycinuria; inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner; inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum

Formal name: N-(3-methyl-1-oxo-2-buten-1-yl)-glycine

Synonyms:  3-MCG|β-Methylcrotonyl Glycine

Molecular weight: 157.2

CAS: 33008-07-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Neuroscience

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