A cinnamic acid derivative that has antidiabetic activity; activates α1-adrenergic receptors (IC50 = 1.4 µM) to enhance secretion of β-endorphin (EC50 = 52.2 nM); increases glucose uptake and enhances glycogen synthesis in isolated soleus muscles of streptozocin-induced diabetic rats; induces a dose-dependent reduction in plasma glucose levels in streptozocin-induced diabetic rats; inhibits absorbance of intestinal maltase and sucrose via α-glucosidase in vitro. (IC50s = 760 and 450 µM

Isoferulic Acid – 1 g

Brand:
Cayman
CAS:
537-73-5
Storage:
-20
UN-No:
Non-Hazardous - /

Isoferulic acid is a cinnamic acid derivative that has antidiabetic activity.{40026,40027} It binds to and activates α1-adrenergic receptors (IC50 = 1.4 µM) to enhance secretion of β-endorphin (EC50 = 52.2 nM) and increase glucose use in vitro. Isoferulic acid increases glucose uptake and enhances glycogen synthesis in isolated soleus muscles from streptozocin-induced diabetic rats.{40025} In vivo, isoferulic acid induces a dose-dependent reduction in plasma glucose levels in streptozocin-induced diabetic rats. It also inhibits absorbance of intestinal maltase and sucrose via α-glucosidase in vitro (IC50s = 760 and 450 µM, respectively).{40028}  

 

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Description

A cinnamic acid derivative that has antidiabetic activity; activates α1-adrenergic receptors (IC50 = 1.4 µM) to enhance secretion of β-endorphin (EC50 = 52.2 nM); increases glucose uptake and enhances glycogen synthesis in isolated soleus muscles of streptozocin-induced diabetic rats; induces a dose-dependent reduction in plasma glucose levels in streptozocin-induced diabetic rats; inhibits absorbance of intestinal maltase and sucrose via α-glucosidase in vitro. (IC50s = 760 and 450 µM, respectively)

Formal name: 3-(3-hydroxy-4-methoxyphenyl)-2-propenoic acid

Synonyms:  3-methoxy Caffeic Acid|3-hydroxy-4-Methoxycinnamic Acid|NSC 51987

Molecular weight: 194.2

CAS: 537-73-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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