A bioactive sphingolipid found in S. cerevisiae

C18 Phytoceramide (t18:0/18:0) – 5 mg

Brand:
Cayman
CAS:
34354-88-6
Storage:
-20
UN-No:
Non-Hazardous - /

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis.{35021,35022,35023,35024} Cer(t18:0/18:0) is composed of a phytosphingosine (Item No. 20217) backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain.{4469,3512,5031} It also inhibits expression of the allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated murine skin tissue.{35021} Formulations containing cer(t18:0/18:0) have been used used in cosmetics as a skin protectants as they reduce water loss to prevent epidermal dehydration and irritation.{35022,35023} [Matreya, LLC. Catalog No. 2034]  

 

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Description

A bioactive sphingolipid found in S. cerevisiae, wheat grains, and mammalian epidermis; has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain; inhibits expression of the allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated tissue; is used in cosmetics as a skin protectant

Formal name: N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-octadecanamide

Synonyms:  C18:0 Phytoceramide|Cer(t18:0/18:0)|Ceramide (t18:0/18:0)|N-Octadecanoyl Phytosphingosine|N-Stearoyl Phytosphingosine|SPS

Molecular weight: 584

CAS: 34354-88-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation|Allergy||Research Area|Lipid Biochemistry|Sphingolipids

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