Description
A cereblon modulator with an IC50 value of 60 nM in a competitive TR-FRET assay; has a higher affinity for cereblon than the related modulators lenalidomide (IC50 = 1,500 nM) and pomalidomide (IC50 = 1,200 nM) in the same assay; has a greater potency for degradation of the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) as well; does not degrade GSPT1 or CK1α ,
Formal name: 3S-[1,3-dihydro-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Synonyms: CC-220
Molecular weight: 449.5
CAS: 1323403-33-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors
