A metabolite of ellagic acid with antiproliferative

Urolithin A – 10 mg

Brand:
Cayman
CAS:
1143-70-0
Storage:
-20
UN-No:
Non-Hazardous - /

Urolithin A is a secondary metabolite of ellagic acid (Item No. 10569), a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.{40131} It decreases proliferation in ECC-1, Ishikawa, and HEC-1A human endometrial cancer cell lines at a concentration of 1 µM, arrests the cell cycle at the G2/M transition, and modulates estrogen receptor-regulated gene expression.{40132} It also potentiates the antiproliferative effect of 5-fluorouracil (Item No. 14416) in Caco-2, SW480, and HT-29 cells.{40128} In a rat model of colitis, urolithin A reduces inflammation, decreasing prostaglandin E2 (PGE2; Item No. 14010) levels and preventing upregulation of COX-2 gene expression and protein levels in colonic mucosa.{40129} It also induces mitophagy in C. elegans, C2C12 myoblasts, and Mode-K intestinal cells in correlation with improved fitness and extended lifespan in C. elegans and increased exercise capacity in mice.{40130}  

 

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Description

A metabolite of ellagic acid with antiproliferative, anti-inflammatory, and anti-oxidant properties; decreases proliferation in human endometrial cancer cell lines at a concentration of 1 µM, arrests the cell cycle at the G2/M transition, and modulates estrogen receptor-regulated gene expression; potentiates the antiproliferative effect of 5-fluorouracil; decreases PGE2 levels and prevents upregulation of COX-2 gene expression and protein levels in a rat model of colitis; induces mitophagy, improves fitness, and extends lifespan of C. elegans; increases exercise capacity in mice

Formal name: 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one

Synonyms:  2′,7-Dihydroxy-3,4-benzocoumarin|3,8-Dihydroxy Urolithin

Molecular weight: 228.2

CAS: 1143-70-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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