A cholesterol ester found in LDL; transferred to the plasma membrane of macrophages and CHO cells expressing CHO via LRP

Cholesteryl Linoleate – 500 mg

Brand:
Cayman
CAS:
604-33-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cholesteryl linoleate is a cholesterol ester found in LDL.{38440} Cholesteryl linoleate is transferred to the plasma membrane of macrophages and CHO cells expressing 15-lipoxygenase (15-LO) via LDL receptor-related protein (LRP), where it undergoes oxidation to form cholesteryl linoleate hydroperoxides (Item No. 48001). Cholesteryl linoleate expression increases 2.7-fold in Apob-lipoproteins in mice overexpressing the human ABCA1 reverse cholesterol transporter, directly correlating with increased levels of hepatic cholesterol and number of atherosclerotic lesions.{38441}  

 

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Description

A cholesterol ester found in LDL; transferred to the plasma membrane of macrophages and CHO cells expressing CHO via LRP, where it undergoes oxidation to form cholesteryl linoleate hydroperoxides; expression increases 2.7-fold in Apob-lipoproteins in mice overexpressing the human ABCA1 reverse cholesterol transporter,

Formal name: cholest-5-en-3β-ol, 3-[(9Z,12Z)-9,12-octadecadienoate]

Synonyms:  Cholesterol Linoleate|Linoleic Acid cholesteryl ester|NSC 18183

Molecular weight: 649.1

CAS: 604-33-1

Purity: ≥98%

Formulation: A waxy crystal

Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Lipid Biochemistry|Sterol Lipids

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