An internal standard for the quantification of losartan (potassium salt) by GC- or LC-MS

Losartan-d4 – 1 mg

Brand:
Cayman
CAS:
1030937-27-9
Storage:
2-8
UN-No:
Non-Hazardous - /

Losartan-d4 contains four deuterium atoms located on the phenyl group. It is intended for use as an internal standard for the quantification of losartan (potassium salt) (Item No. 10006594) by GC- or LC-MS. Losartan is an antagonist of the angiotensin (AT) II receptor subtype AT1 with a Ki value of 5-20 nM.{12997} It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats.{12998,13089} Formulations containing losartan have been used to control hypertension while protecting renal function.{12996}  

 

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Description

An internal standard for the quantification of losartan (potassium salt) by GC- or LC-MS,

Formal name: 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl-2,3,5,6-d4]methyl]-1H-imidazole-5-methanol

Synonyms: 

Molecular weight: 426.9

CAS: 1030937-27-9

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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