A naturally occurring ceramide; is formed when C12 sphingomyelin is hydrolyzed by ASM; substrate for acid ceramidase

C12 Ceramide (d18:1/12:0) – 10 mg

Brand:
Cayman
CAS:
74713-60-3
Storage:
-20
UN-No:
Non-Hazardous - /

C12 ceramide is a naturally occurring ceramide that is formed when C12 sphingomyelin is hydrolyzed by acid sphingomyelinase (ASM).{38210} It is a substrate for acid ceramidase, an enzyme that has 2- to 12-fold higher activity in fibroblasts from patients with Farber disease, a lipid storage disorder.{38209} C12 ceramide is found in the Wharton’s jelly, a protective coating that surrounds umbilical cord vessels, of babies born to women with pre-eclampsia.{38208} BODIPY C12 ceramide has been used to assess levels of ASM activity in plasma of patients with type A or B Niemann-Pick disease.{38210}  

 

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Description

A naturally occurring ceramide; is formed when C12 sphingomyelin is hydrolyzed by ASM; substrate for acid ceramidase, an enzyme which has 2- to 12-fold higher activity in fibroblasts from patients with Farber disease; found in the Wharton’s jelly of babies born to women with pre-eclampsia,

Formal name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-dodecanamide

Synonyms:  C12 Ceramide|Cer(d18:1/12:0)|Ceramide (d18:1/12:0)|N-Lauroyl-D-erythro-Sphingosine

Molecular weight: 481.8

CAS: 74713-60-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Lipid Biochemistry|Sphingolipids

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