A sphingolipid pathway intermediate; natural isomer of dihydrosphingosine (sphinganine) that acts as a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases; increases in response to heat stress

Sphinganine (d20:0) – 1 mg

Brand:
Cayman
CAS:
24006-62-0
Storage:
-20
UN-No:
Non-Hazardous - /

Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); Item No. 10007945) that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) (Item No. 62570). In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation.{36119} Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers.{18300,18298,18299} Sphinganine can block protein kinase C activation in some cases but not others.{18301,15200} [Matreya, LLC. Catalog No. 1845]  

 

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Description

A sphingolipid pathway intermediate; natural isomer of dihydrosphingosine (sphinganine) that acts as a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases; increases in response to heat stress, indicating it is involved in heat stress adaptation in S. cerevisiae; levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers; can block protein kinase C activation

Formal name: 2S-amino-1,3R-eicosanediol

Synonyms:  D-erythro-C20-Dihydrosphingosine|D-erythro-Sphinganine C20|Eicosasphinganine

Molecular weight: 329.6

CAS: 24006-62-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Toxicology|Environmental

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