A bioactive sphingolipid; an intermediate in the metabolism of glycosphingolipids and sphingolipids; acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM); prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion

Sphinganine-1-phosphate (d18:0) – 1 mg

Brand:
Cayman
CAS:
19794-97-9
Storage:
-20
UN-No:
Non-Hazardous - /

Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM).{40334} Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively.{40336} It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.{40335,18303}  

 

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Description

A bioactive sphingolipid; an intermediate in the metabolism of glycosphingolipids and sphingolipids; acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM); prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively; has antifibrotic effects in scleroderma fibroblasts

Formal name: 2(S)-amino-1,3(R)-octadecanediol, 1-(dihydrogen phosphate)

Synonyms:  C18-dihydro Sphingosine-1-phosphate|D-erythro-Sphinganine-1-phosphate|dihydro-D-erythro-Sphingosine-1-phosphate

Molecular weight: 381.5

CAS: 19794-97-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Lipid Biochemistry|Sphingolipids

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