A calcium channel blocker with analgesic effects (ED50 = 2.5 mg/kg in STZ-induced diabetic rats); does not inhibit rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg)

Mirogabalin – 1 mg

Brand:
Cayman
CAS:
1138245-13-2
Storage:
-20
UN-No:
Non-Hazardous - /

Mirogabalin is a calcium channel blocker with analgesic effects.{36068} It binds to the α2δ-1 and α2δ-2 subunits of voltage-dependent Ca2+ channels. Mirogabalin has potent and sustained analgesic effects (ED50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; Item No. 13104). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose. Formulations containing mirogabalin are in clinical trials for diabetic peripheral neuropathic pain.{36067}  

 

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Description

A calcium channel blocker with analgesic effects (ED50 = 2.5 mg/kg in STZ-induced diabetic rats); does not inhibit rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose,

Formal name: (1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo[3.2.0]hept-3-ene-6-acetic acid

Synonyms:  DS-5565

Molecular weight: 209.3

CAS: 1138245-13-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Research Area|Neuroscience|Pain Research

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