A flavonoid with diverse bioactivities; inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 µM); prevents Aβ (1-42) mature fibril remodeling; inhibits the production of cytokines

Brazilin – 50 mg

Brand:
Cayman
CAS:
474-07-7
Storage:
-20
UN-No:
Non-Hazardous - /

Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.{41009} Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 µM) more potently than (-)-epigallocatechin gallate (Item No. 70935), cucurmin (Item No. 81025), and resveratrol (Item Nos. 10004235 | 70675).{41007} It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 (Item No. 14010) and TNF-α (IC50s = 12.6 and 87.2 µM).{41011} It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 µg/ml.{41010} In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.{41008}  

 

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Description

A flavonoid with diverse bioactivities; inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 µM); prevents Aβ (1-42) mature fibril remodeling; inhibits the production of cytokines, including PGE2 and TNF-α (IC50s = 12.6 and 87.2 µM); effective against Gram-positive and Gram-negative bacteria MICs = 31.3-250 µg/ml; inhibits RANKL-mediated osteoclast differentiation; protective against LPS-induced osteoporosis in mice (100 mg/kg)

Formal name: 7,11bR-dihydro-benz[b]indeno[1,2-d]pyran-3,6aS,9,10(6H)-tetrol

Synonyms:  (+)Brazilin|NSC 56652

Molecular weight: 286.3

CAS: 474-07-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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