A metabolite of diclofenac; acutely toxic in vitro; may play a role in the hepatotoxicity of diclofenac in vivo; binds OATs (Km = 60.2

Diclofenac Acyl-β-D-Glucuronide – 500 µg

Brand:
Cayman
CAS:
64118-81-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Diclofenac acyl-β-D-glucuronide is an active metabolite of diclofenac (Item No. 70680) and the predominant metabolite in rat.{36041} Diclofenac acyl-β-D-glucuronide is acutely toxic in vitro, suggesting it may play a role in the hepatotoxicty of diclofenac in vivo.{36040} Diclofenac acyl-β-D-glucuronide binds to organic anion transporters (OATs; Km = 60.2, 8.6, 112, and 103.9 µM for OAT1-4, respectively) as well as multi-drug resistance proteins.{36043} High levels of diclofenac are found in waste water treatment plant samples, which may be due to the back-transformation of diclofenac acyl-β-D-glucuronide to diclofenac.{36042}  

 

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Description

A metabolite of diclofenac; acutely toxic in vitro; may play a role in the hepatotoxicity of diclofenac in vivo; binds OATs (Km = 60.2, 8.6, 112, and 103.9 µM for OAT1-4, respectively); may be back-transformed to diclofenac in wastewater,

Formal name: β-D-glucopyranuronic acid, 1-[2-[(2,6-dichlorophenyl)amino]benzeneacetate]

Synonyms: 

Molecular weight: 472.3

CAS: 64118-81-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Toxicology|Drug Metabolism|Drug Metabolites||Research Area|Toxicology|Environmental

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