A saponin from Astragalus; has osteogenic activities in vitro; induces differentiation and matrix mineralization of MC3T3-E1 cells; increases alkaline phosphatase activity; increases expression of osteoblast-related genes (10-40 µM)

Astragaloside I – 5 mg

Brand:
Cayman
CAS:
84680-75-1
Storage:
-20
UN-No:
Non-Hazardous - /

Astragaloside I is a saponin originally isolated from the dried plant roots of Astragalus, which is used in traditional Chinese medicine.{27380} Astragaloside I has osteogenic activities in vitro.{38156} It induces differentiation and matrix mineralization of MC3T3-E1 cells, a murine osteoblastic cell line, and increases alkaline phosphatase activity. It also increases the expression of osteoblast-related genes in a concentration-dependent manner (10-40 µM), including genes in the Wnt/β-catenin pathway.  

 

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Description

A saponin from Astragalus; has osteogenic activities in vitro; induces differentiation and matrix mineralization of MC3T3-E1 cells; increases alkaline phosphatase activity; increases expression of osteoblast-related genes (10-40 µM), including Wnt/β-catenin,

Formal name: (3β,6α,16β,20R,24S)-3-[(2,3-di-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside

Synonyms:  AS-I|AST-I

Molecular weight: 869

CAS: 84680-75-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Small Molecule Activators||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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