A flavonoid from C. ordata with anticancer and antiplasmodial activity; inhibits the viability of HL-60

4′-O-methyl Quercetin – 500 µg

Brand:
Cayman
CAS:
603-61-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

4′-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4′-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM.{39035} It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4′-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy.{39036} 4′-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).{39037}  

 

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Description

A flavonoid from C. ordata with anticancer and antiplasmodial activity; inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM; induces G2-M arrest and inhibits tubulin polymerization in vitro; inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 0.040 μM in a vesicular transport assay); reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM),

Formal name: 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  4′-methoxy Quercetin|Tamarixetin

Molecular weight: 316.3

CAS: 603-61-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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