An IFN induction pathway inhibitor (IC50 = 4.1 µM in a GFP reporter assay for IFN induction); reduces IFN-β mRNA levels; selectively inhibits the IFN induction pathway but not the IFN signaling pathway

StA-IFN-1 – 1 mg

Brand:
Cayman
CAS:
300839-31-0
Storage:
-20
UN-No:
Non-Hazardous - /

StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 µM in a GFP reporter assay for IFN induction similar to TPCA-1 (Item No. 15115), which specifically inhibits the IKKβ component of the IFN induction pathway.{37091} It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib (Item No. 11609), which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.  

 

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Description

An IFN induction pathway inhibitor (IC50 = 4.1 µM in a GFP reporter assay for IFN induction); reduces IFN-β mRNA levels; selectively inhibits the IFN induction pathway but not the IFN signaling pathway

Formal name: 4-(1-acetyl-1H-indol-3-yl)-2,4-dihydro-5-methyl-3H-pyrazol-3-one

Synonyms: 

Molecular weight: 255.3

CAS: 300839-31-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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