An inhibitor of the Lin28/let-7 interaction (IC50 = 8 μM in a competition ELISA); increases levels of endogenous let-7 miRNAs and decreases Lin28 expression in a dose-dependent manner in mESCs; inhibits clonogenic growth of 22Rv1

Lin28 1632 – 10 mg

Brand:
Cayman
CAS:
108825-65-6
Storage:
-20
UN-No:
Non-Hazardous - /

Lin28 1632 is a small molecule inhibitor of the interaction between the RNA binding protein Lin28 and let-7 precursor RNA (IC50 = 8 μM in a competition ELISA).{41072} It increases levels of endogenous let-7 miRNAs and decreases Lin28 expression in a dose-dependent manner in murine embryonic stem cells (mESCs). Lin28 1632 inhibits clonogenic growth of 22Rv1, PC3, DU145, and Huh7 cancer cells and decreases tumor-sphere formation by 22Rv1 and Huh7 cells in vitro. It also binds bromodomain-containing protein 4 (BRD4) and CREB-binding protein (CBP/CREBBP) bromodomains (Kds = 7 and 25 μM, respectively).  

 

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Description

An inhibitor of the Lin28/let-7 interaction (IC50 = 8 μM in a competition ELISA); increases levels of endogenous let-7 miRNAs and decreases Lin28 expression in a dose-dependent manner in mESCs; inhibits clonogenic growth of 22Rv1, PC3, DU145, and Huh7 cancer cells and decreases tumor-sphere formation by 22Rv1 and Huh7 cells in vitro; binds BRD4 and CBP bromodomains (Kds = 7 and 25 μM, respectively)

Formal name: N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-acetamide

Synonyms: 

Molecular weight: 281.3

CAS: 108825-65-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cancer Stem Cell Research||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains

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