An internal standard for the quantification of temozolomide by GC- or LC-MS

Temozolomide-d3 – 5 mg

Brand:
Cayman
CAS:
208107-14-6
Storage:
2-8
UN-No:
Non-Hazardous - /

Temozolomide-d3 (TMZ-d3) contains three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of temozolomide (Item No. 14163) by GC- or LC-MS. TMZ is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} Formulations containing TMZ are effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}  

 

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Description

An internal standard for the quantification of temozolomide by GC- or LC-MS,

Formal name: 3,4-dihydro-3-(methyl-d3)-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

Synonyms:  Methazolastone-d3|TMZ-d3

Molecular weight: 197.2

CAS: 208107-14-6

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Cancer|DNA Damage and Repair

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