An inhibitor of Eg5 (IC50 = 200 nM in an ATPase assay); selective for Eg5 over other kinesin subfamilies from four different organisms; induces accumulation of HeLa cells in the G2/M phase (75% at a concentration of 1 μM); inhibits spindle formation and induces radial arrangement of chromosomes in Xenopus oocytes; inhibits migration and growth of PANC-1 pancreatic cancer cells in a concentration-dependent manner; inhibits angiogenesis and induces severe circulation defects in zebrafish embryos

Dimethylenastron – 5 mg

Brand:
Cayman
CAS:
863774-58-7
Storage:
-20
UN-No:
Non-Hazardous - /

Dimethylenastron is an inhibitor of the mitotic kinesin Eg5 (IC50 = 200 nM in an ATPase assay).{40431} It is selective for Eg5 over other kinesin subfamilies from four different organisms. Dimethylenastron induces accumulation of HeLa cells in the G2/M phase (75% at a concentration of 1 μM). It inhibits spindle formation and induces radial arrangement of chromosomes in Xenopus oocytes. Dimethylenastron inhibits migration and growth of PANC-1 pancreatic cancer cells in a concentration-dependent manner.{40432} Dimethylenastron also inhibits angiogenesis and induces severe circulation defects in zebrafish embryos.{40433}  

 

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Description

An inhibitor of Eg5 (IC50 = 200 nM in an ATPase assay); selective for Eg5 over other kinesin subfamilies from four different organisms; induces accumulation of HeLa cells in the G2/M phase (75% at a concentration of 1 μM); inhibits spindle formation and induces radial arrangement of chromosomes in Xenopus oocytes; inhibits migration and growth of PANC-1 pancreatic cancer cells in a concentration-dependent manner; inhibits angiogenesis and induces severe circulation defects in zebrafish embryos

Formal name: 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone

Synonyms: 

Molecular weight: 302.4

CAS: 863774-58-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Migration & Metastasis

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