An indirect activator of STING signaling; induces IRF3- and IFN-dependent transcription in human fibroblasts

G10 – 5 mg

Brand:
Cayman
CAS:
702662-50-8
Storage:
-20
UN-No:
Non-Hazardous - /

G10 is an indirect activator of stimulator of interferon genes (STING) signaling.{37248} It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively). G10 (100 µM) increases phosphorylation of IRF3, which is lost in cells lacking STING.  

 

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Description

An indirect activator of STING signaling; induces IRF3- and IFN-dependent transcription in human fibroblasts, PBMCs, and HUMECs; prevents replication of chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively); increases phosphorylation of IRF3 when used at a concentration of 100 µM but not in cells lacking STING

Formal name: 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide

Synonyms:  STING Agonist-1

Molecular weight: 430.9

CAS: 702662-50-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Activators||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease|Viral Diseases|Chikungunya

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