A BKCa channel activator; increases maximum potassium current to 126% of control X. laevis oocytes expressing human BKCa channels at 1 μM; increases the diameter of retinal arterioles in rats from 10-100 μg/kg

BMS 191011 – 50 mg

Brand:
Cayman
CAS:
202821-81-6
Storage:
-20
UN-No:
- 2811 / 6.1

BMS 191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels that increases maximum potassium current to 126% of control in X. laevis oocytes expressing human BKCa channels when used at a concentration of 1 μM.{47157} In vivo, BMS 191011 (10-100 μg/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the BKCa channel blocker iberiotoxin (Item No. 14608).{47158}  

 

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Description

A BKCa channel activator; increases maximum potassium current to 126% of control X. laevis oocytes expressing human BKCa channels at 1 μM; increases the diameter of retinal arterioles in rats from 10-100 μg/kg

Formal name: 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

Synonyms: 

Molecular weight: 370.7

CAS: 202821-81-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Ophthalmology

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