An inhibitor of the MAD2-CDC20 interaction; inhibits MAD2 binding to GST-CDC20111-138 in a concentration-dependent manner when used at concentrations ranging from 6.25-100 μM; reduces mitotic duration in HeLa cells treated with paclitaxel at a concentration of 25 μM

M2I-1 – 10 mg

Brand:
Cayman
CAS:
312271-03-7
Storage:
-20
UN-No:
Non-Hazardous - /

M2I-1 is an inhibitor of the interaction between spindle assembly checkpoint protein MAD2 and CDC20, a coactivator of the anaphase promoting complex/cyclosome (APC/C).{38568} In vitro, M2I-1 (6.25-100 μM) inhibits MAD2 binding to GST-CDC20111-138 in a concentration-dependent manner. M2I-1 also reduces mitotic duration in HeLa cells treated with paclitaxel (Item No. 10461) at a concentration of 25 μM.  

 

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Description

An inhibitor of the MAD2-CDC20 interaction; inhibits MAD2 binding to GST-CDC20111-138 in a concentration-dependent manner when used at concentrations ranging from 6.25-100 μM; reduces mitotic duration in HeLa cells treated with paclitaxel at a concentration of 25 μM ,

Formal name: 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

Synonyms: 

Molecular weight: 404.5

CAS: 312271-03-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Cycle

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