A selective κ1-opioid receptor partial agonist (Ki = 32.6); inhibits forskolin-stimulated cAMP production (EC50 = 4.7 nM); antinociceptive effects in mice at 13 µg

Salvinorin A Propionate – 10 mg

Brand:
Cayman
CAS:
689295-71-4
Storage:
-20
UN-No:
Non-Hazardous - /

Salvinorin A propionate is a selective partial agonist at κ1-opioid receptors (KOR) with a Ki value of 32.6 nM.{34652} It inhibits adenylate cyclase (EC50 = 4.7 nM) in HEK293 cells transfected with human KOR.{34651} It is selective for KORs over µ, δ, and ORL-1 opioid receptors and has no effect at serotonin, dopamine, muscarinic, or adrenergic receptors. In mice, salvinorin A propionate (13 µg, i.c.v.) reduces nociceptive responses in a radiant heat tail-flick assay, though not as potently as salvinorin A (Item No. 11487).{34652}  

 

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Description

A selective κ1-opioid receptor partial agonist (Ki = 32.6); inhibits forskolin-stimulated cAMP production (EC50 = 4.7 nM); antinociceptive effects in mice at 13 µg, i.c.v.

Formal name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-9-(1-oxopropoxy)-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester

Synonyms:  Salvinorinyl-2-propionate

Molecular weight: 446.5

CAS: 689295-71-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Pain Research

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