A triterpenoid saponin natural product; has antiproliferative activity against HepG2 (IC50s = 15.5 μM) and HeLa cells (IC50 = 25 μM); induces nuclear condensation and fragmentation

Tubeimoside I – 5 mg

Brand:
Cayman
CAS:
102040-03-9
Storage:
-20
UN-No:
Non-Hazardous - /

Tubeimoside I is a natural triterpenoid saponin isolated from the medicinal herb B. paniculatum which possesses broad anticancer activity.{39096,39097,39098,39099} Tubeimoside I exhibits antiproliferative activity against hepatoma HepG2 cells (IC50 = 15.5 μM) and induces nuclear condensation and fragmentation, cell cycle arrest, mitochondrial membrane disruption, and activation of caspase-3 and caspase-9.{39096} Treatment of HeLa cells with tubeimoside I (IC50 = 25 μM) similarly initiates mitochondrial dysfunction, endoplasmic reticulum stress, and cytoskeletal rearrangement.{39097} In vivo, tubeimoside I (5 mg/kg) administration to nude mice with flank xenografts of human large-cell lung carcinoma cells decreases tumor volume and microvessel density.{39098} It also decreases metastasis of breast cancer cell line MDA-MB-231 in vivo by decreasing expression of C-X-C chemokine receptor type 4 (CXCR4).{39099}  

 

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Description

A triterpenoid saponin natural product; has antiproliferative activity against HepG2 (IC50s = 15.5 μM) and HeLa cells (IC50 = 25 μM); induces nuclear condensation and fragmentation, cell cycle arrest, mitochondrial membrane disruption, and apoptosis; decreases tumor volume and microvessel density in vivo in NCI-H460 flank xenografts (5 mg/kg); decreases metastasis and CXCR4 in vivo in a breast cancer MDA-MB-231 model

Formal name: (2β,3β,4α)-olean-12-en-28-oic acid, 3-[[2-O-[4-O-[(3S)-4-carboxy-3-hydroxy-3-methyl-1-oxobutyl]-α-L-arabinopyranosyl]-β-D-glucopyranosyl]oxy]-2,23-dihydroxy-28-(O-β-D-xylopyranosyl-(1→3)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl) ester, intramol. 4”(3)→4”(28)-ester

Synonyms:  Lobatoside H|Tubeimoside A

Molecular weight: 1,319.40

CAS: 102040-03-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Mitochondrial Biology

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