A natural steroid glycoside with diverse effects; inhibits LPS-stimulated increases in VCAM-1 and ICAM-1 expression; reverses LPS-stimulated decreases in the expression of IκBα in HUVECs in a dose-dependent manner; reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells; lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin

Ginsenoside Rb2 – 5 mg

Brand:
Cayman
CAS:
11021-13-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ginsenoside Rb2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.{24877} It inhibits LPS-stimulated increases in vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression in vitro. It dose-dependently reverses LPS-induced decreases in the expression of IκBα in human umbilical vein endothelial cells (HUVECs).{25807} Ginsenoside Rb2 reduces adhesion of THP-1 cells to LPS-stimulated HUVEC cells, also in a dose-dependent manner. Ginsenoside Rb2 reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells.{25810} It also lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin (Item No. 10010338).{39216}  

 

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Description

A natural steroid glycoside with diverse effects; inhibits LPS-stimulated increases in VCAM-1 and ICAM-1 expression; reverses LPS-stimulated decreases in the expression of IκBα in HUVECs in a dose-dependent manner; reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells; lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin ,

Formal name: (3β,12β)-20-[(6-O-α-L-arabinopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

Synonyms:  Ginsenoside C|NSC 308878

Molecular weight: 1,079.30

CAS: 11021-13-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|ECM & Adhesion Molecules

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