Description
An alkaloid with diverse biological activities; inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 μM, respectively); inhibits the growth of HL-60, U937, and K562 leukemia cell lines (IC50s = 40, 270, and 360 μM, respectively); reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension; reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-α, IL-1β, and IL-6 in a mouse model of allergic contact dermatitis,
Formal name: 1,3,4,6R,6aR,7,8,9,10,12,13R,13aS-dodecahydro-6,13-methano-2H-dipyrido[1,2-a:3′,2′-e]azocine
Synonyms:
Molecular weight: 232.4
CAS: 56293-29-9
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Immunology & Inflammation|Allergy||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Oxidative Stress & Reactive Species
