A selective κ-opioid receptor agonist; more potent than salvinorin A in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM

Salvinorin B Mesylate – 5 mg

Brand:
Cayman
CAS:
862073-79-8
Storage:
-20
UN-No:
Non-Hazardous - /

Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A (Item No. 11487) in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively).{34566,34288} It is a mesylated version of salvinorin B (Item No. 11488) and is highly selective for κ-opioid receptors over µ- and δ-opioid receptors.{34566} In vitro, it increases dopamine uptake via the dopamine transporter (DAT) in an ERK1/2-dependent manner but does not alter expression of DAT on the cell membrane.{34567} In rats, it increases the pain threshold and blocks reinstatement of cocaine drug-seeking.  

 

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Description

A selective κ-opioid receptor agonist; more potent than salvinorin A in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively); increases dopamine uptake in an ERK1/2-dependent manner; increases the pain threshold and blocks reinstatement of cocaine drug-seeking in rats

Formal name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-9-[(methylsulfonyl)oxy]-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester

Synonyms:  Mesyl Sal B

Molecular weight: 468.5

CAS: 862073-79-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Pain Research

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