A phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist; a complex of theophylline and ethylenediamine; has in vivo bronchodilator and vasodilator activity; suppresses visceral hypersensitivity to colorectal distension in rat IBS-D model; provides renoprotection against murine renal ischemia-reperfusion injury

Aminophylline – 100 g

Brand:
Cayman
CAS:
317-34-0
Storage:
22
UN-No:
Limited Quantity - 2811 / 6.1

Aminophylline is a competitive and non-selective phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist.{37006,37010} It is a complex of theophylline and ethylenediamine that has in vivo bronchodilator and vasodilator effects.{37006,37007} Aminophylline suppresses maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension in a rat model of irritable bowel syndrome with diarrhea (IBS-D).{37008} Aminophylline also provides renoprotection against murine renal ischemia-reperfusion injury.{37009}  

 

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Description

A phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist; a complex of theophylline and ethylenediamine; has in vivo bronchodilator and vasodilator activity; suppresses visceral hypersensitivity to colorectal distension in rat IBS-D model; provides renoprotection against murine renal ischemia-reperfusion injury

Formal name: 3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione 1,2-ethanediamine (2:1)

Synonyms: 

Molecular weight: 210.2

CAS: 317-34-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Gastric Disease|IBS

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