An anticancer compound; inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells from ≤5-10 nM; decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells at 10 nM; reduces tumor volume (MED = 50 mg/kg) and decreases the number of vasculogenic mimicry channels in tumors at 100 mg/kg in an HCT116 colon cancer mouse xenograft model; reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner at 7.5

TRX-818 (sodium salt) – 1 mg

Brand:
Cayman
CAS:
1256037-62-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

TRX-818 is an anticancer compound.{53140,53141} It inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells when used at concentrations ranging from less than or equal to 5 to 10 nM. {53140} TRX-818 (10 nM) decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells. It reduces tumor volume with a minimum effective dose (MED) value of 50 mg/kg and decreases the number of vasculogenic mimicry channels in tumors when administered at a dose of 100 mg/kg in an HCT116 colon cancer mouse xenograft model. TRX-818 (7.5, 15, and 30 mg/kg) reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner.{53141}  

 

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Description

An anticancer compound; inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells from ≤5-10 nM; decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells at 10 nM; reduces tumor volume (MED = 50 mg/kg) and decreases the number of vasculogenic mimicry channels in tumors at 100 mg/kg in an HCT116 colon cancer mouse xenograft model; reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner at 7.5, 15, and 30 mg/kg

Formal name: 2-(3-fluorophenyl)-6-methoxy-5-(phosphonooxy)-4(1H)-quinolinone, disodium salt

Synonyms: 

Molecular weight: 409.2

CAS: 1256037-62-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis

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