Description
A potent inhibitor of PDE10A (IC50 = 0.3 nM); >15,000-fold selective for PDE10A over other PDEs and exhibits <50% inhibition at 91 receptors, ion channels, and enzymes at a concentration of 10 μM; increases cAMP and cGMP levels by 1.3- and 2.14-fold, respectively, in the striatum of mice when administered at a dose of 0.3 mg/kg; reverses PCP-induced hyperlocomotion (MED = 0.3 mg/kg, p.o.) in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg; reverses (+)-MK-801-induced hyperlocomotion (MED = 0.1 mg/kg, p.o.) but has no effect on plasma prolactin or glucose levels in rats,
Formal name: 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-4(1H)-pyridazinone
Synonyms:
Molecular weight: 428.4
CAS: 1238697-26-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Neuroscience|Behavioral Neuroscience
