An agonist of GPR119; inhibits hepatic lipid accumulation in wild-type

MBX-2982 – 5 mg

Brand:
Cayman
CAS:
1037792-44-1
Storage:
-20
UN-No:
Non-Hazardous - /

MBX-2982 is a agonist of GPR119.{36741} It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet. It also increases plasma levels of glucagon-like peptide 1 (GLP-1; Item No. 24460) in mice when administered at a dose of 10 mg/kg prior to, and to a greater extent following, glucose administration.{36742} MBX-2982 increases glucokinase activity in an enzyme assay with an EC50 value of 45.11 µM.{36743}  

 

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Description

An agonist of GPR119; inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet at 10 mg/kg; increases plasma levels of GLP-1 in mice at 10 mg/kg prior to and following glucose administration; increases glucokinase activity in an enzyme assay (EC50 = 45.11 µM)

Formal name: 5-ethyl-2-[4-[4-[[4-(1H-tetrazol-1-yl)phenoxy]methyl]-2-thiazolyl]-1-piperidinyl]-pyrimidine

Synonyms: 

Molecular weight: 448.5

CAS: 1037792-44-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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