A lipid-soluble form of vitamin B1; corrects defective replication of

Benfotiamine – 500 mg

Brand:
Cayman
CAS:
22457-89-2
Storage:
-20
UN-No:
Non-Hazardous - /

Benfotiamine is a lipid-soluble form of vitamin B1 (thiamine).{37093} In vitro, it corrects defective replication of, and prevents formation of advanced glycosylation end products (AGEs) in, human umbilical vein endothelial cells (HUVECs) grown under high glucose conditions.{37094} In vivo, administration of benfotiamine increases nerve conduction velocity (NCV) and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes.{37093,37095} Benfotiamine reduces liver levels of aspartate and alanine aminotransferases, markers of hepatic damage, and lipid peroxidation in a rat model of acute ethanol intoxication.{37096} Administration of benfotiamine reduces the number of amyloid plaques and amount of phosphorylated tau in a transgenic mouse model of Alzheimer’s disease.{37097} It also improves spatial memory performance in the Morris water maze.  

 

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Description

A lipid-soluble form of vitamin B1; corrects defective replication of, and prevents formation of AGEs in, HUVECs grown under high glucose conditions; increases NCV and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes; reduces levels of aspartate and alanine aminotransferase and lipid peroxidation in livers in a rat model of acute ethanol intoxication; reduces the number of amyloid plaques and amount of phosphorylated tau in brains in a transgenic mouse model of Alzheimer’s disease

Formal name: benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester

Synonyms:  Benzoylthiamine monophosphate

Molecular weight: 466.5

CAS: 22457-89-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Vitamins||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Carbohydrate Oxidation||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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