An internal standard for the quantification of FK-506 by GC- or LC-MS

FK-506-13C-d2 – 1 mg

Brand:
Cayman
CAS:
1356841-89-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

FK-506-13C-d2 contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 (Item No. 10007965) by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin.{5285} Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation.{13842} The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors.{7042} In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors “leaky” to Ca2+.  

 

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Description

An internal standard for the quantification of FK-506 by GC- or LC-MS,

Formal name:

Synonyms:  Tacrolimus-13C-d2

Molecular weight: 807

CAS: 1356841-89-8

Purity: ≥99% deuterated forms (d1-d2); ≤1% d0

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|13C||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Neuroscience

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