A polypeptide antibiotic mixture produced by B. brevis

Tyrothricin – 5 mg

Brand:
Cayman
CAS:
1404-88-2
Storage:
-20
UN-No:
Non-Hazardous - /

Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis.{38058,38059} Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica.{38059} Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections.{38058,38059}  

 

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Description

A polypeptide antibiotic mixture produced by B. brevis, composed of tyrocidine and gramicidin with rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica; i.v. use leads to hemolysis and lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively)

Formal name:

Synonyms: 

Molecular weight: 1,270.50

CAS: 1404-88-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Antibiotics|Polypeptides||Product Type|Biochemicals|Antiparasitics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Chagas Disease||Research Area|Infectious Disease|Parasitic Diseases|Leishmaniasis||Research Area|Infectious Disease|Parasitic Diseases|Trichomoniasis

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