An inhibitor of arginase types I and II; inhibits rat liver arginase I (Kis = 0.4 and 0.6 µM from kinetic analyses); inhibits human arginase II (Kis = 310 and 30 nM at pH 7.5 and 9.5

BEC (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
222638-67-7
Storage:
-20
UN-No:
Non-Hazardous - /

BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}  

 

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Description

An inhibitor of arginase types I and II; inhibits rat liver arginase I (Kis = 0.4 and 0.6 µM from kinetic analyses); inhibits human arginase II (Kis = 310 and 30 nM at pH 7.5 and 9.5, respectively); enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro at 0.1-1 mM

Formal name: S-(2-boronoethyl)-L-cysteine, monohydrochloride

Synonyms: 

Molecular weight: 229.5

CAS: 222638-67-7

Purity: ≥95%

Formulation: A crystalline solid

Application|Enzyme Activity||Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Cardiovascular System|Vasculature|Vasodilation

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