A potent NS3/4A protease inhibitor (Ki = 0.36 nM); inhibits HCV viral replication (EC50 = 7.8 nM); effective against the HCV genotypes 1a and 1b in biochemical assays; works synergistically with IFN-α or NM-107 in replicon cells; works additively with ribavirin in replicon cells

Simeprevir (sodium salt) – 1 mg

Brand:
Cayman
CAS:
1241946-89-3
Storage:
-20
UN-No:
Non-Hazardous - /

Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication.{38234} It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays.{38233} In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin (Item No. 16757). Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.  

 

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Description

A potent NS3/4A protease inhibitor (Ki = 0.36 nM); inhibits HCV viral replication (EC50 = 7.8 nM); effective against the HCV genotypes 1a and 1b in biochemical assays; works synergistically with IFN-α or NM-107 in replicon cells; works additively with ribavirin in replicon cells,

Formal name: (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, sodium salt

Synonyms: 

Molecular weight: 749.9

CAS: 1241946-89-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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