Description
A dual inhibitor of c-Met and VEGFR2; inhibits autophosphorylation of c-Met and phosphorylation of VEGFR2 (IC50s = 14 and 16 nM, respectively); inhibits proliferation in a variety of cancer cell lines; inhibits proliferation of HUVECs stimulated with HGF and VEGF but not bFGF (IC50s = 17, 84, and >1,000 nM); reduces tumor volume dose-dependently in nude mouse xenograft models using MKN45, Hs746T, SNU-5, or EBC-1 cells; increases survival of nude mice implanted with MKN45 cancer cells
Formal name: N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N’-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Synonyms: E7050
Molecular weight: 633.7
CAS: 928037-13-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling
