An antagonist of the Smo receptor (IC50 = 0.64 μM in a luciferase reporter assay); inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 μM) when expressed in HEK293 cells

MRT10 – 5 mg

Brand:
Cayman
CAS:
330829-30-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

MRT10 is an antagonist of the Smoothened (Smo) receptor with an IC50 value of 0.64 μM in a luciferase reporter assay.{24331,38182} It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 μM) when expressed in HEK293 cells.{24331}  

 

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Description

An antagonist of the Smo receptor (IC50 = 0.64 μM in a luciferase reporter assay); inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 μM) when expressed in HEK293 cells ,

Formal name: N-[[[3-(benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxy-benzamide

Synonyms: 

Molecular weight: 465.5

CAS: 330829-30-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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