A HAT inhibitor (IC50s = 74 and 47 μM

MG149 – 1 mg

Brand:
Cayman
CAS:
1243583-85-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

MG149 is a histone acetyltransferase (HAT) inhibitor with IC50 values of 74 and 47 μM, for human recombinant Tip60 and males absent on the first (MOF) HATs, respectively.{41057,41058} MG149 targets the acetyl-CoA binding site and inhibits acetyltransferase activity in the nuclear extract from murine hippocampus, amygdala, and prefrontal cortex.{41059} MG149 also inhibits the p53 and NF-κB pathways.  

 

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Description

A HAT inhibitor (IC50s = 74 and 47 μM, for human Tip60 and MOF, respectively); targets the acetyl-CoA binding site; inhibits acetyltransferase activity in the nuclear extract from murine hippocampus, amygdala, and prefrontal cortex; inhibits the p53 and NF-κB pathways

Formal name: 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-benzoic acid

Synonyms: 

Molecular weight: 340.5

CAS: 1243583-85-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Immunology & Inflammation

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