Description
An orally bioavailable helicase-primase inhibitor; inhibits the ATPase activity of HSV helicase-primase (IC50 = 30 nM); inhibits HSV replication in Vero cells (IC50 = 20 nM for both HSV-1 and HSV-2); active against porcine and bovine HSV strains (IC50s = 5 and 0.12 μM, respectively); effective against HSV-1 and HSV-2 in a lethal challenge model (ED50 = 0.5 mg/kg in mice and rats) and in a zosteriform spread model, at a dose of 15 mg/kg, in mice and Lewis rats; reduces levels of Aβ and phosphorylated Tau production in HSV-1 infected Vero cells
Formal name: N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)-benzeneacetamide
Synonyms:
Molecular weight: 402.5
CAS: 348086-71-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals|Helicase-primase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV
