A hydrophilic metabolite of dexamethasone; can be used to determine CYP3A4 enzyme activity; male rats produce similar amounts as humans; female rats produce fewer hydroxylated metabolites than male rats and humans

6β-hydroxy Dexamethasone – 500 µg

Brand:
Cayman
CAS:
55879-47-5
Storage:
-20
UN-No:
Non-Hazardous - /

6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound.{37032} Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans.{37031,37034} The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount.{37033} In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.  

 

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Description

A hydrophilic metabolite of dexamethasone; can be used to determine CYP3A4 enzyme activity; male rats produce similar amounts as humans; female rats produce fewer hydroxylated metabolites than male rats and humans

Formal name: 9-fluoro-6β,11β,17,21-tetrahydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

Synonyms:  6​β​-hydroxydexamethasone|6-hydroxyDEX|6OH-DEX

Molecular weight: 408.5

CAS: 55879-47-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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