An oxidative metabolite of bexarotene; binds to RXRα

6-hydroxy Bexarotene – 5 mg

Brand:
Cayman
CAS:
368451-07-4
Storage:
-20
UN-No:
Non-Hazardous - /

6-hydroxy Bexarotene is an oxidative metabolite of bexarotene (Item No. 11571), a high-affinity ligand for retinoid X receptors (RXRs).{35324} 6-hydroxy Bexarotene binds to RXRα, RXRβ, and RXRγ as well as retinoic acid receptor α (RARα; Kds = 3.46, 4.21, 4.83, and 8.17 μM, respectively). It selectively activates RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively).  

 

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Description

An oxidative metabolite of bexarotene; binds to RXRα, RXRβ, and RXRγ as well as RARα (Kds = 3.46, 4.21, 4.83, and 8.17 μM, respectively); selectively activates RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively)

Formal name: 4-[1-(5,6,7,8-tetrahydro-6-hydroxy-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-benzoic acid

Synonyms: 

Molecular weight: 364.5

CAS: 368451-07-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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