An internal standard for the quantification of omeprazole by GC- or LC-MS

Omeprazole-d3 – 5 mg

Brand:
Cayman
CAS:
934293-92-2
Storage:
22
UN-No:
Non-Hazardous - /

Omeprazole-d3 is intended for use as an internal standard for the quantification of omeprazole (Item No. 14880) by GC- or LC-MS. Omeprazole is a selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 1.1 μM).{14045} It is a racemic mixture of two enantiomers, S-omeprazole (esomeprazole magnesium; Item No. 17326) and R-omeprazole (sodium salt) (Item No. 18874), which are prodrugs of the active sulfonamide which is formed by acid-stimulated conversion.{18256,18249} Both enantiomers are extensively metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4.{18249}  

 

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Description

An internal standard for the quantification of omeprazole by GC- or LC-MS,

Formal name: 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-4,5,7-d3

Synonyms:  OMEP-d3|OMP-d3|OMZ-d3

Molecular weight: 348.4

CAS: 934293-92-2

Purity: ≥99% deuterated forms (d1-d3); ≤1% d0

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Gastric Disease

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