An ATP analog with antithrombic properties; inhibits platelet aggregation (IC50 = 0.4 nM); reversible competitive antagonist of the P2Y12 receptor; reduces ADP-induced blood clotting in a mouse model of pulmonary thromoembolism

Cangrelor (sodium salt) – 1 mg

Brand:
Cayman
CAS:
163706-36-3
Storage:
4
UN-No:
Non-Hazardous - /

Cangrelor is an ATP analog that inhibits platelet aggregation (IC50 = 0.4 nM).{40206} It is a reversible competitive antagonist of the platelet purinergic P2Y12 receptor.{23699,40207} Pretreatment with cangrelor significantly reduces blood clotting induced by ADP in a mouse model of pulmonary thromboembolism.{40208} Formulations containing cangrelor have been used to prevent blood clotting in at-risk patients.{40209}  

 

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Description

An ATP analog with antithrombic properties; inhibits platelet aggregation (IC50 = 0.4 nM); reversible competitive antagonist of the P2Y12 receptor; reduces ADP-induced blood clotting in a mouse model of pulmonary thromoembolism

Formal name: N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5′-adenylic acid, anhydride with P,P’-(dichloromethylene)bis[phosphonic acid], tetrasodium salt

Synonyms:  AR-C69931MX

Molecular weight: 864.3

CAS: 163706-36-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis

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