An inhibitor of PGC-1α

SR 18292 – 5 mg

Brand:
Cayman
CAS:
2095432-55-4
Storage:
-20
UN-No:
Non-Hazardous - /

SR 18292 is an inhibitor of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), a coactivator of transcription factors for genes involved in gluconeogenesis.{37125} SR 18292 (20 µM) increases acetylation of PGC-1α and, subsequently, decreases mRNA expression of phosphoenolpyruvate carboxykinase 1 (PEPCK1/Pck1) and the glucose-6-phosphatase catalytic subunit (G6Pc) in primary hepatocytes following stimulation with glucagon. In a dietary model of type II diabetes mellitus in mice, SR 18292 (45 mg/kg, i.p., for four days) reduces fasting blood glucose levels and the expression of liver Pck1. It also enhances glucose tolerance and insulin sensitivity in two mouse models of obesity.  

 

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Description

An inhibitor of PGC-1α, increases acetylation of PGC-1α; decreases mRNA expression of Pck1 and G6Pc in primary hepatocytes following glucagon stimulation; reduces fasting blood glucose and Pck1 expression in the liver in a dietary model of type II diabetes in mice at a dose of 45 mg/kg, i.p, for four days; enhances glucose tolerance and insulin sensitivity in two mouse models of obesity

Formal name: 1-[(1,1-dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-2-propanol

Synonyms: 

Molecular weight: 366.5

CAS: 2095432-55-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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