A partial agonist of serotonin 5-HT1A receptors (Ki = 10 nM in hippocampal membranes); reduces 5-HT release in rat ventral hippocampus in vivo; low doses decrease

Ipsapirone – 10 mg

Brand:
Cayman
CAS:
95847-70-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ipsapirone is a partial agonist of the serotonin (5-HT) receptor 5-HT1A (Ki = 10 nM in hippocampal membranes).{35118} It reduces 5-HT release in rat ventral hippocampus in vivo.{35119} Low doses of ipsapirone decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens.{35120} Extracellular dopamine levels in murine striatum increase following administration of ipsapirone at concentrations >0.1 mg/kg. Ipsapirone has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively).{35121} Formulations containing ipsapirone have been used to treat depression and borderline personality disorder.{35122}  

 

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Description

A partial agonist of serotonin 5-HT1A receptors (Ki = 10 nM in hippocampal membranes); reduces 5-HT release in rat ventral hippocampus in vivo; low doses decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens; extracellular dopamine levels in murine striatum increase following administration at concentrations >0.1 mg/kg; has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively)

Formal name: 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one, 1,1-dioxide

Synonyms:  TVXQ 7821

Molecular weight: 401.5

CAS: 95847-70-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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