A depsipeptide antifungal; inhibits ERG synthesis (IC50 = 34 ng/ml); selectively inhibits growth of C. albicans (MIC = 32 µg/ml); acts synergistically with fluconazole to reduce growth of azole-resistant C. albicans (MIC = 0.0016 µg/ml); hydroxy form of PF-1163A

PF-1163B – 2.5 mg

Brand:
Cayman
CAS:
258871-60-2
Storage:
-20
UN-No:
Non-Hazardous - /

PF-1163B is a depsipeptide antifungal isolated from Penicillium that inhibits ergosterol (ERG) synthesis (IC50 = 34 ng/ml).{39013,39015} It inhibits growth of C. albicans (MIC = 32 µg/ml) but not of other Candida strains, A. fumigatus, or HepG2 cells.{39013} It acts synergistically with fluconazole (Item No. 11594) to reduce growth of azole-resistant C. albicans (MIC = 2 and 0.0016 µg/ml alone and in combination, respectively).{39014} PF-1163B is a hydroxy form of PF-1163A (Item No. 22065).  

 

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Description

A depsipeptide antifungal; inhibits ERG synthesis (IC50 = 34 ng/ml); selectively inhibits growth of C. albicans (MIC = 32 µg/ml); acts synergistically with fluconazole to reduce growth of azole-resistant C. albicans (MIC = 0.0016 µg/ml); hydroxy form of PF-1163A,

Formal name: 3S-[[4-(2-hydroxyethoxy)phenyl]methyl]-4,10R-dimethyl-13R-pentyl-1-oxa-4-azacyclotridecane-2,5-dione

Synonyms: 

Molecular weight: 461.6

CAS: 258871-60-2

Purity: ≥95%

Formulation: An oil

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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