An isoxazoline ectoparasiticide; selectively inhibits binding of EBOB

Fluralaner – 25 mg

Brand:
Cayman
CAS:
864731-61-3
Storage:
-20
UN-No:
Non-Hazardous - /

Fluralaner is an isoxazoline ectoparasiticide.{36084,36085} It potently and selectively inhibits binding of the GABA receptor channel blocker [3H]4′-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly head membranes, with an IC50 value of 455 pM as compared to an IC50 value of >10 μM for rat brain membranes.{36084} Fluralaner blocks GABA- and glutamate-induced chloride currents in Xenopus oocytes expressing housefly MdGBCl or MdGluCl channels (IC50s = 5.32 and 79.9 nM, respectively) but has no effect on rat GABA Cl channels (IC50 = >30,000 nM). It has insecticidal and acaricidal activity against C. felis, S. calcitrans, L. cuprina, A. aegypti, R. microplus, R. sanguineus, and O. moubata at concentrations of 0.0000012 to 1 ppm.{36085} Formulations containing fluralaner have been used to treat parasitic infections in dogs, cats, and hedgehogs.{36086,36087,36088}  

 

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Description

An isoxazoline ectoparasiticide; selectively inhibits binding of EBOB, a GABA channel blocker, to housefly head membranes (IC50 = 455 pM versus >10 μM in rat membranes); blocks GABA- and glutamate-induced chloride currents in Xenopus oocytes expressing housefly MdGBCl or MdGluCl channels (IC50s = 5.32 and 79.9 nM, respectively); has insecticidal and acaricidal activity at concentrations of 0.0000012 to 1 ppm

Formal name: 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-benzamide

Synonyms:  A-1443|AH 252723

Molecular weight: 556.3

CAS: 864731-61-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Pesticides|Acaricides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Toxicology|Environmental

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