An LPA1 receptor antagonist (IC50 = 0.16 µM); selective LPA1 over the LPA2 and LPA3 receptors (IC50s = 8.6 and >10 µM

ONO-7300243 – 5 mg

Brand:
Cayman
CAS:
638132-34-0
Storage:
-20
UN-No:
De Minimis - 3077 / 9

ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 = 0.16 µM).{43205} It is selective for LPA1 over the LPA2 and LPA3 receptors (IC50s = 8.6 and >10 µM, respectively). ONO-7300243 dose-dependently reduces intraurethral pressure induced by LPA in rats (ID50 = 11.6 mg/kg) without affecting mean blood pressure.  

 

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Description

An LPA1 receptor antagonist (IC50 = 0.16 µM); selective LPA1 over the LPA2 and LPA3 receptors (IC50s = 8.6 and >10 µM, respectively); reduces LPA-induced intraurethral pressure induced by LPA in rats (ID50 = 11.6 mg/kg)

Formal name: 4-[[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl]-benzeneacetic acid

Synonyms: 

Molecular weight: 461.6

CAS: 638132-34-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Kidney & Renal Disease

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