An ansamycin antibiotic and antifungal; inhibits bone resorption (IC50 = 21 nM) and pp60c-src kinase (IC50 = 50 nM); inhibits L-leucine incorporation during protein synthesis (IC50 = 58 nM); inhibits TNF-α-induced ICAM1 expression (IC50 = 300 nM); potentiates the action of chemotherapeutics; hydroquinone of ansatrienin A

Ansatrienin B – 5 mg

Brand:
Cayman
CAS:
82189-04-6
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis.{37029},{37026} In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM).{37028} It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells).{37025} It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil (Item No. 14416), cisplatin (Item No. 13119), bleomycin (Item No. 13877), mitomycin C (Item No. 11435), and 6-mercaptopurine.{37027} Ansatrienin B is a hydroquinone form of ansatrienin A (Item No. 21995).{37026}  

 

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Description

An ansamycin antibiotic and antifungal; inhibits bone resorption (IC50 = 21 nM) and pp60c-src kinase (IC50 = 50 nM); inhibits L-leucine incorporation during protein synthesis (IC50 = 58 nM); inhibits TNF-α-induced ICAM1 expression (IC50 = 300 nM); potentiates the action of chemotherapeutics; hydroquinone of ansatrienin A

Formal name: N-(cyclohexylcarbonyl)-D-alanine, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester

Synonyms:  Mycotrienin II|SDZ-115 962

Molecular weight: 638.8

CAS: 82189-04-6

Purity: ≥95%

Formulation: A powder

Product Type|Biochemicals|Antibiotics|Ansamycins||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases

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